Population
Cell-free systems from interferon-treated, vaccinia virus-infected mouse L-cells and Krebs 2 ascites tumour…
Comparison
Interferon treatment prior to infection and… vs Cell-free systems from untreated vaccinia…
Design
Preclinical
Authors
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May inform interferon mechanisms in EMCV myocarditis models; leaves open human cardiovascular translation.
The study demonstrates that interferon-mediated inhibition of viral RNA translation occurs primarily at initiation, which can be bypassed by formylmethionyl-tRNAF.
Kerr et al. (1974) studied this question.
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