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March 1, 1978European Journal of BiochemistryOpen Access

Synthesis of an Oligonucleotide Inhibitor of Protein Synthesis in Rabbit Reticulocyte Lysates Analogous to that Formed in Extracts from Interferon‐Treated Cells

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Population

Rabbit reticulocyte lysates and mouse L-cell extracts

Comparison

Synthesis of an oligonucleotide inhibitor using… vs Inhibitor synthesized with extracts from…

Design

Preclinical

Authors

AHAra G. HovanessianDélégation Paris 5IKIan M. KerrThe Honourable Society of Lincoln's Inn

Discussion

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Implication

Validates reticulocyte lysates as a model for interferon-induced inhibition; extends cell-free observations but leaves open in vivo relevance.

Structured PICO

P
Population
Rabbit reticulocyte lysates and mouse L-cell extracts
I
Intervention
Synthesis of an oligonucleotide inhibitor using ATP and double-stranded RNA (dsRNA)
C
Comparator
Inhibitor synthesized with extracts from interferon-treated mouse L-cells; haemin-controlled repressor
O
Outcome
Inhibition of protein synthesis and characterization of the synthesized inhibitor (absorbance spectra, chromatographic and electrophoretic properties)surrogate

The study demonstrates that an oligonucleotide inhibitor of protein synthesis formed in rabbit reticulocyte lysates is identical to that produced in interferon-treated cells.

Cite This Study

Hovanessian et al. (1978) studied this question.

synapsesocial.com/papers/6a871d93540b033b21bf0cf0https://doi.org/10.1111/j.1432-1033.1978.tb12151.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interferon‐Mediated Inhibition of Cell‐Free‐Protein Synthesis in Response to Double‐Stranded RNA1976 · 72 citations
  2. 2Inhibition of Protein Synthesis in Cell-Free Systems from Interferon-Treated, Infected Cells: Further Characterization and Effect of Formylmethionyl-tRNA F1974 · 50 citations
  3. 3Blocks in Elongation and Initiation of Protein Synthesis Induced by Interferon Treatment in Mouse L Cells1975 · 70 citations
  4. 4Translation of murine leukemia virus RNA in cell-free systems from animal cells1976 · 117 citations
  5. 5Heterogneeous 5'-terminal structures occur on vesicular stomatitis virus mRNAs.1975 · 114 citations