Key result
In isolated perfused rabbit proximal convoluted tubules, the transtubular potential difference was -5.80 mV at perfusion flow rates above 10 nl/min, but decreased precipitously at slower flow rates.
Population
Isolated segments of proximal convoluted tubules obtained from female New Zealand rabbits
Comparison
Varying perfusion flow rates, temperature… vs Control conditions
Design
Preclinical
Authors
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Flow dependence of proximal tubule potential in rabbits warrants caution in isolated tubule models; leaves open relevance to human renal physiology.
The study demonstrates that the proximal tubule of the rabbit has a flow- and transport-dependent transtubular potential difference of approximately -5.8 mV.
Kokko et al. (1971) studied Normal physiology (isolated rabbit proximal convoluted tubules). Perfusion flow rate vs. <10 nl/min was evaluated on Transtubular potential difference (pd). In isolated perfused rabbit proximal convoluted tubules, the transtubular potential difference was -5.80 mV at perfusion flow rates above 10 nl/min, but decreased precipitously at slower flow rates.
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