May 1, 1981AJP Renal Physiology

Electrical effects of acidification in the rabbit proximal convoluted tubule

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Population

Isolated rabbit proximal convoluted tubules (PCT)

Comparison

Carbonic anhydrase inhibitors, lowering bath… vs Baseline conditions

Design

Preclinical

Authors

CBChristine BerryDuke Medical Center

Discussion

Member takes

Implication

Does not support independent electrogenic acidification in rabbit proximal tubule; leaves open its role in other species or disease models.

Structured PICO

Population

Isolated rabbit proximal convoluted tubules (PCT)

Intervention

Carbonic anhydrase inhibitors, lowering bath sodium bicarbonate concentration, anion transport inhibitor SITS, and removal of glucose and alanine from luminal fluid

Comparator

Baseline conditions (perfused and bathed with an ultrafiltrate-like solution)

Outcome

Transepithelial potential difference (transport PD) and rate of total CO2 absorptionsurrogate

The findings do not support an independent electrogenic acidification mechanism in the rabbit proximal convoluted tubule.

Cite This Study

Christine Berry (1981) studied this question.

synapsesocial.com/papers/6a9e719bc9425f9df3f588fa https://doi.org/10.1152/ajprenal.1981.240.5.f459

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Implication

Does not support independent electrogenic acidification in rabbit proximal tubule; leaves open its role in other species or disease models.