Key result
Basolateral, but not luminal, CO2/HCO3- stimulated both a luminal Na+/H+ exchanger and a luminal H+ pump, increasing the rate of intracellular pH recovery from an acid load.
Population
Isolated perfused S3 segment of the rabbit proximal tubule
Comparison
Addition of CO2/HCO3- to the lumen only or to… vs Bilateral CO2/HCO3- addition or controls in the…
Design
Preclinical
Authors
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Warrants caution against clinical translation from rabbit models; extends mechanistic insight into proximal tubule acid-base transport.
Basolateral, but not luminal, CO2/HCO3- stimulates both a luminal Na+/H+ exchanger and a luminal H+ pump in the S3 segment of the rabbit proximal tubule.
Chen et al. (1995) studied this question. Basolateral CO2/HCO3- vs. Luminal CO2/HCO3- or controls was evaluated on Intracellular pH (pHi) recovery rate from an acid load. Basolateral, but not luminal, CO2/HCO3- stimulated both a luminal Na+/H+ exchanger and a luminal H+ pump, increasing the rate of intracellular pH recovery from an acid load.
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