Key result
Acetate transport in the rabbit proximal tubule alkalinizes the cell via luminal entry of Na+/Ac- followed by luminal and basolateral exit of acetic acid.
Population
Isolated perfused S3 segments of the rabbit proximal tubule
Comparison
Addition or removal of 10 mM or 0.5 mM acetate… vs Baseline conditions or alternative acetate…
Design
Preclinical
Authors
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Hypothesis-generating for tubular pH regulation; leaves open translation to human renal physiology or clinical acid-base disorders.
The study demonstrates the presence of a Na+/Ac- cotransporter at the luminal membrane and pathways for acetic acid transport at both luminal and basolateral membranes in the rabbit proximal tubule.
Nakhoul et al. (1988) studied this question. Acetate (Ac-) transport manipulation was evaluated on Intracellular pH (pHi) changes. Acetate transport in the rabbit proximal tubule alkalinizes the cell via luminal entry of Na+/Ac- followed by luminal and basolateral exit of acetic acid.
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