Digoxin-Quinidine Interaction: Current Status

Editorial Notes1 November 1980Digoxin-Quinidine Interaction: Current StatusEDWARD B. LEAHEY JR, M.D.EDWARD B. LEAHEY JR, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-5-775 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptQuinidine has been the prototype of antiarryhthmic drug since it was introduced into clinical practice in 1918, and it is widely used for treatment of both atrial and ventricular arrhythmias. Patients given quinidine frequently are also receiving a digitalis preparation because they have ventricular failure as well as cardiac arrhythmia, and because digitalis is frequently used to slow the ventricular response to atrial fibrillation when quinidine is used to convert the fibrillation to sinus rhythm. Despite the frequent combined administration of these two drugs, interaction between quinidine and digoxin was only recognized in 1978 (1-3).Radioimmunoassay of serum digoxin concentration...References1. LEAHEY E, REIFFEL J, DRUSIN R, HEISSENBUTTEL R, LOVEJOY W, and BIGGER J. Interaction between digoxin and quinidine. JAMA. 1978;240:533-4. CrossrefMedlineGoogle Scholar2. EJVINSSON G. Effect of quinidine on plasma concentrations of digoxin. Br Med J. 1978;1:279-80. CrossrefMedlineGoogle Scholar3. DOERING W and KÖNIG E. Ansteig der Digoxinkonzentration in Serum unter Chinidinmedikation. Med Klin. 1978;73:1085-8. MedlineGoogle Scholar4. LEAHEY E, REIFFEL J, GIARDINA E, and BIGGER J. The effect of quinidine and other oral antiarrhythmic drugs on serum digoxin: a prospective study. Ann Intern Med. 1980;92:605-08. LinkGoogle Scholar5. MUNGALL D, ROBICHAUX R, and PERRY W. Effects of quinidine on serum digoxin concentrations: a prospective study. Ann Intern Med. 1980;93:689-93. 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Clin Res. 1980;28:475A. Abstract. Google Scholar12. LEAHEY E, CARSON J, BIGGER J, and BUTLER V. Reduced renal clearance of digoxin during chronic quinidine administration. Circulation. 1979;60 (Suppl II):16. Abstract. MedlineGoogle Scholar13. HOOYMANS P, HOLFORD N, MASSIE B, WITT M, PLUYM B, and MERKUS F. Quinidine decreases both renal and metabolic clearance of digoxin. Am J Cardiol. 1980;45:453. Abstract. CrossrefGoogle Scholar14. FENSTER P, POWELL J, HAGER W, GRAVES P, CONRAD K, and GOLDMAN S. Onset and dose dependence of the digoxin-quinidine interaction. Am J Cardiol. 1980;45:413. Abstract. CrossrefGoogle Scholar15. LEAHEY E, BIGGER J, and BUTLER V. Quinidine concentration dependent decrease in digoxin clearance in man. Circulation 1980; in press. Abstract. Google Scholar16. STEINESS E, WALDORFF S, BO HANSEN P, KJAERGAARD H, BUCH J, and EGEBLAD H. Reduction of digoxin-induced inotropism during quinidine administration. Clin Pharmacol Ther. 1980;27:791-5. CrossrefMedlineGoogle Scholar17. SMITH T. Digitalis toxicity: epidemiology and clinical use of serum concentration measurements. Am J Med. 1975;58:470-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD B. LEAHEYJR, M.D.Affiliations: Department of Medicine College of Physicians and Surgeons Columbia University New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDigoxin: The Monarch of Cardiac ToxicitiesStandards of laboratory practice: cardiac drug monitoringSome pharmacokinetic and pharmacodynamic interactions between digoxin and gentamicinDigoxin quinidine interaction: A pharmacokinetic study in the isolated perfused rat liverUpdate of cardiovascular drug interactionsDigoxin toxicity possibly precipitated by trazodoneWithdrawing digoxin —Wortha tryDetermination of quinidine in serum by spectrofluorometry, liquid chromatography and fluorescence scanning thin-layer chromatographyVerapamil therapy for stable and unstable angina pectoris: Calcium channel antagonists in perspectiveThe influence of verapamil on serum digoxin concentration.Digoxin Use in the Elderly[42] Immunoassay of digoxin and other cardiac glycosidesA Digoxin-Antibiotic Drug InteractionPharmacotherapy of Cardiac Arrhythmia 1 November 1980Volume 93, Issue 5Page: 775-776KeywordsArrhythmiaAtrial fibrillationAttentionDrug interactionsDrugsRadioimmunoassays ePublished: 1 December 2008 Issue Published: 1 November 1980 PDF downloadLoading ...