Key result
Nasopharyngeal flocked swab collection was superior to nasal wash for detecting respiratory viruses by multiplex PCR, with a sensitivity of 89.6% versus 79.2% (P=0.0043).
Why the study?
Does nasopharyngeal flocked swabbing improve the detection of respiratory viruses compared to nasal washes in pediatric outpatients with acute respiratory illness?
Cross-Sectional (n=299)
Single-blind (laboratory technicians blinded to specimen pairing)
No
Does nasopharyngeal flocked swabbing improve the detection of respiratory viruses compared to nasal washes in pediatric outpatients with acute respiratory illness?
Absolute Event Rate: 89.6% vs 79.2%
p-value: p=0.0043
Nasopharyngeal flocked swabbing offers a more sensitive and acceptable alternative to nasal washes for detecting respiratory viruses in pediatric outpatients.
Nasopharyngeal flocked swabs were associated with higher viral detection sensitivity in children; leaves open whether this should alter outpatient practice.
Detection of respiratory viruses by real-time multiplexed PCR (M-PCR) and of respiratory syncytial virus (RSV) by M-PCR and immunofluorescence (IF) was evaluated using specimens collected by nasopharyngeal flocked swabbing (NFS) and nasal washes (NW). In children with mild respiratory illness, NFS collection was superior to NW collection for detection of viruses by M-PCR (sensitivity, 89.6% versus 79.2%; P = 0.0043). NFS collection was noninferior to NW collection in the detection of RSV by IF.
No takes yet. Share an insight, caveat, or question.
Munywoki et al. (2011) conducted a cross-sectional in Acute respiratory illness (n=299). Nasopharyngeal flocked swab vs. Nasal wash was evaluated on Sensitivity for detection of respiratory viruses by multiplex PCR (p=0.0043). Nasopharyngeal flocked swab collection was superior to nasal wash for detecting respiratory viruses by multiplex PCR, with a sensitivity of 89.6% versus 79.2% (P=0.0043).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: