Multifunctional catalysts in operation: A novel class of trifunctional thiourea catalysts containing natural amino acid residues have been prepared (see scheme), and found to be very effective towards the asymmetric addition of 3-alkyl-oxindoles to 1,1-bis(benzenesulfonyl)ethylene. This synthetic protocol has led to the enantioselective synthesis of 3-alkyl-3-aryl-disubstituted oxindoles and indolines with an all-carbon quaternary stereogenic center.
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Zhu et al. (2010) studied this question.
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