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Deoxydative acetoxylation of 3‐methoxy‐, 3‐phenyl‐, 3‐methyl‐, 3‐chloro‐, and 3‐methoxycar‐bonylpyrazine 1‐oxides furnished predominantly 2‐acetoxy‐6‐substituted pyrazines, some of which were more selectively prepared by addition of zinc bromide and triethylamine to the reaction. Regioselectivity of the acetoxylation is discussed based upon heat of formation by AMI and AMI‐COSMO for all possible isomers of each set.
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Sato et al. (1994) studied this question.
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