Ahstract-After a short description of the main characteristics of biomimetic NADH models, the choice of optically active amino alcohols as chiral auxiliaries is justified.The literature results in this field are then reviewed.The results obtained with 1,4-dihydropyridines, annelated models in the thiophene and pyrrole series are particularly discussed.The main factors responsible of a good enantioselectivity are emphasized and applied to the design of a highly enantioselective NADH model in the 1,6-naphtyridinone series.
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Bourguignon et al. (1994) studied this question.
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