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Summary. NANA is known to be part of the M and N antigenic receptors. Despite this, the oldest population of red cells in a blood sample agglutinates more strongly with anti‐M and ‐N reagents even though the total NANA content of the cells is lower than that of the youngest population. Removal of small amounts of NANA by the action of neuraminidase results in increased agglutinability with human anti‐M and ‐N and with rabbit anti‐N but not with rabbit anti‐M. Each reagent (human and rabbit anti‐M; human, rabbit and lectin anti‐N) produces a different pattern of agglutination with progressively neuraminidase treated cells, probably indicating that antisera from human, rabbit and seed sources react with different portions of the receptors. The variations in behaviour of human and rabbit anti‐M and anti‐N reagents can be more easily explained by these observations.
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Greenwalt et al. (1973) studied this question.
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