Key result
Acute HIV infection was associated with elevated NT-proBNP (79 vs 28 pg/mL; P<.001) and troponin T (4.9 vs 1.5 ng/L; P<.001), which decreased following viral suppression.
Why the study?
Does viral suppression reduce NT-proBNP and troponin T levels in patients with acute HIV infection?
Observational (n=49)
Does viral suppression reduce NT-proBNP and troponin T levels in patients with acute HIV infection?
Absolute Event Rate: 79% vs 28%
p-value: p=<.001
Acute HIV infection is associated with reversible subclinical inflammatory cardiomyopathy, evidenced by elevated NT-proBNP and troponin T levels that decrease upon viral suppression.
No takes yet. Share an insight, caveat, or question.
May prompt biomarker monitoring in acute HIV; leaves open whether early suppression prevents cardiomyopathy.
Schuster et al. (2018) conducted an observational in Acute HIV infection (n=49). Acute HIV infection vs. Viral suppression phase was evaluated on N-terminal prohormone of brain natriuretic peptide levels (p=<.001). Acute HIV infection was associated with elevated NT-proBNP (79 vs 28 pg/mL; P<.001) and troponin T (4.9 vs 1.5 ng/L; P<.001), which decreased following viral suppression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: