Synthesis of a β-Hexapeptide from (R)-2-Aminomethyl-alkanoic Acids and Structural Investigations

All articles of this category The ( R ) α-branched β-amino acid derivatives 3-5 with the side chains of alanine, valine and leucine are prepared by amino-methylation of acyloxazolidinones 2a-c and are used for the synthesis of the trifluoroacetate salt 9 of H(-β 2 -HVal-β 2 -HAla-β 2 -HLeu) 2 -OH. The CD spectrum of compound 9 is compared with that of the isomer H(-β 3 -HVal-β 3 -HAla-β 3 -HLeu) 2 -OH ( 1 ) built from the corresponding β-branched β-amino acids. α-branched β-amino acids - diastereoselective synthesis - β-peptides - CD-spectroscopy - 3 1 helix