December 1, 1983BloodOpen Access

Quinidine-induced thrombocytopenia and leukopenia: demonstration and characterization of distinct antiplatelet and antileukocyte antibodies

View Full Paper

Ask AI

Bookmark

Population

1 patient with simultaneous quinidine-induced thrombocytopenia and leukopenia

Design

Case_report

Authors

BCBH ChongPrince of Wales Hospital MBMC BerndtSouth Australia Pathology JKJ Koutts

Discussion

Member takes

Implication

Alerts clinicians to dual antibody mechanisms in quinidine cytopenias; extends drug-dependent models but remains hypothesis-generating.

Structured PICO

Population

1 patient with simultaneous quinidine-induced thrombocytopenia and leukopenia

Intervention

In vitro characterization of serum antibodies using platelet aggregometry, immunofluorescence, leukoagglutination, and immunoprecipitation

Outcome

Detection and characterization of quinidine-dependent antiplatelet and antileukocyte antibodiessurrogate

Quinidine-induced thrombocytopenia and leukopenia can be mediated by two distinct, drug-dependent IgG antibodies targeting different cell surface receptors.

Cite This Study

Chong et al. (1983) studied this question.

synapsesocial.com/papers/6a97401663baccaa47af026e https://doi.org/10.1182/blood.v62.6.1218.bloodjournal6261218

View Full Paper

Ask AI

Bookmark

Quinidine-induced thrombocytopenia and leukopenia: demonstration and characterization of distinct antiplatelet and antileukocyte antibodies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Quinidine-induced thrombocytopenia and leukopenia: demonstration and characterization of distinct antiplatelet and antileukocyte antibodies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider