Quinine‐ and quinidine platelet antibodies can react with GPIIb/IIIa

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Population

Normal platelets and platelets from patients with Bernard-Soulier syndrome, tested with two quinine- and two…

Design

Preclinical

Authors

Discussion

Extends known targets of drug-dependent antibodies to GPIIb/IIIa; hypothesis-generating in animal models, should not yet change practice.

Population

Normal platelets and platelets from patients with Bernard-Soulier syndrome, tested with two quinine- and two quinidine-dependent antibodies

Intervention

Quinine and quinidine at high (300 microM) and pharmacologic (10 microM) concentrations

Outcome

Drug-dependent antibody binding and precipitation of platelet membrane glycoproteins (GPIb/IX and GPIIb/IIIa)surrogate

Quinine- and quinidine-dependent antiplatelet antibodies can target GPIIb/IIIa in addition to the classically recognized GPIb/IX complex.

Christie et al. (1987) studied this question.

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