This review highlights the critical role of blood pressure management and appropriate anticoagulation, including the use of DOACs, in preventing stroke among patients with hypertension and atrial fibrillation.
May support strict BP control plus risk-stratified NOACs in hypertensive nonvalvular AF; leaves open optimal targets for prospective trials.
高血圧は脳卒中の最大の危険因子である．血圧値と脳卒中発症率には強い正の相関があり，降圧治療は脳卒中の予防に極めて有効である．再発予防においても降圧治療は有効であり，個々の症例の病態に応じた降圧治療が重要である．心房細動は心原性脳塞栓症の重要な危険因子である．非弁膜症性心房細動は男性に多く加齢とともに増加する．脳梗塞発症予防のために，発症リスクを勘案した抗凝固療法が重要である．
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Takanari Kitazono (2012) conducted a review in Hypertension, nonvalvular atrial fibrillation, chronic kidney disease, and stroke. Antihypertensive and anticoagulant therapies was evaluated.
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