Key result
Bolus injections of isoproterenol with atropine displaced the heart rate dose-response curve for atenolol to the right, whereas continuous infusions displaced curves for both beta-blockers to the left.
Why the study?
How does reflex vagal tone contribute to the hemodynamic response to intravenous isoproterenol in the presence of beta-antagonists in healthy subjects?
Population
12 healthy subjects
Comparison
Intravenous isoproterenol by both bolus… vs Within-subject comparisons
Design
Other
Authors
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Isoproterenol administration method may alter beta-blocker dose ratios via vagal reflexes in healthy subjects; leaves open implications for clinical testing.
How does reflex vagal tone contribute to the hemodynamic response to intravenous isoproterenol in the presence of beta-antagonists in healthy subjects?
The method of isoproterenol administration (bolus vs. continuous) elicits contrasting reflex vagal tone responses, which can affect the dose ratios obtained for beta-antagonists.
Arnold et al. (1986) studied Healthy subjects (n=12). Isoproterenol (bolus injection vs continuous infusion) vs. Before and after atropine, and during atenolol and propranolol was evaluated on Heart rate dose-response curve displacement. Bolus injections of isoproterenol with atropine displaced the heart rate dose-response curve for atenolol to the right, whereas continuous infusions displaced curves for both beta-blockers to the left.
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