Key result
White tea infusions significantly decreased TNF-α, NF-κB, IL-6, and caspase-3 levels (p=0.02) in rats with cisplatin-induced renal dysfunction compared to cisplatin alone.
Why the study?
Nephrotoxicity is the most important side effect of cisplatin, restricting its use, and the protective effects of white tea infusions against cisplatin-induced renal damage required investigation.
Does white tea infusion reduce cisplatin-induced nephrotoxicity in female rats?
Does white tea infusion reduce cisplatin-induced nephrotoxicity in female rats?
p-value: p=0.02
White tea infusions significantly reduced cisplatin-induced nephrotoxicity in a rat model, likely due to anti-inflammatory and anti-apoptotic effects.
White tea effects in cisplatin-exposed rats are hypothesis-generating; human trials needed before any clinical consideration.
OBJECTIVE: Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. The aim of this study was to investigate the protective effects of white tea infusions (WT) against renal damage induced by cisplatin (CP) in rats by biochemical and histopathological means. MATERIALS AND METHODS: This study used 24 female Sprague Dawley rats at 12-14 weeks of age and weighing 250-300 g. Rats were divided into three groups: Control, CP and CP + WT groups. CP was injected 7 mg/kg i.p as a single dose/rat in the CP group. White tea was given at a dose of 0.5% (w/v) for 4 weeks. At the end of the experiment, blood urea nitrogen (BUN), creatinine, uric acid, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nuclear factor kappa B (NF-κB) along with caspase-3 in the kidney were evaluated in study. RESULTS: BUN, creatinine, TNF-α, NF-κB and IL-6 levels of the CP group showed a statisically significant increase in comparison to the control group. TNF-α, NF-κB and IL-6 levels showed a statistically significant decrease in the CP + WT group with respect to the CP group. Caspase-3 levels in tubular epithelial cells decreased in CP + WT group compared with CP group (p = 0.02). CONCLUSION: White tea infusions reduced significantly the nephrotoxicity of CP. The anti-nephrotoxic feature of the infusion may be attributed primarily to its anti-inflammatory and anti-apoptotic characteristics.
No takes yet. Share an insight, caveat, or question.
Saral et al. (2019) studied Cisplatin-related renal dysfunction (n=24). White tea infusions vs. Cisplatin alone and Control was evaluated on BUN, creatinine, uric acid, TNF-α, IL-6, NF-κB, and caspase-3 levels (p=0.02). White tea infusions significantly decreased TNF-α, NF-κB, IL-6, and caspase-3 levels (p=0.02) in rats with cisplatin-induced renal dysfunction compared to cisplatin alone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: