Key result
Left atrial assist device support in a mock circulatory loop maintained adequate cardiac output (3.4-3.8 L/min) and aortic pressure (90-105 mm Hg) across various heart rates and diastolic heart failure conditions.
Why the study?
To assess the hemodynamic effects of a newly developing left atrial assist device for HFpEF under normal and various diastolic heart failure conditions using a mock circulatory loop.
Does a left atrial assist device improve hemodynamic parameters in an in vitro model of diastolic heart failure?
Does a left atrial assist device improve hemodynamic parameters in an in vitro model of diastolic heart failure?
p-value: p=not significant
An experimental left atrial assist device improved hemodynamics in a mock circulatory loop simulating HFpEF, suggesting potential feasibility for future development.
We are developing a new left atrial assist device (LAAD) for patients who have heart failure with preserved ejection fraction (HFpEF). This study aimed to assess the hemodynamic effects of the LAAD under both normal heart conditions and various diastolic heart failure (DHF) conditions using a mock circulatory loop. A continuous-flow pump that simulates LAAD, was placed between the left atrial (LA) reservoir and a pneumatic ventricle that simulated a native left ventricle on a pulsatile mock loop. Normal heart (NH) and mild, moderate, and severe DHF conditions were simulated by adjusting the diastolic drive pressures of the pneumatic ventricle. With the LAAD running at 3200 rpm, data were collected at 60, 80, and 120 bpm of the pneumatic ventricle. Cardiac output (CO), mean aortic pressure (AoP), and mean LA pressure (LAP) were compared to evaluate the LAAD performance. With LAAD support, the CO and AoP rose to a sufficient level at all heart rates and DHF conditions (CO; 3.4-3.8 L/min, AoP; 90-105 mm Hg). Each difference in the CO and the AoP among various heart rates was minuscule compared with non-pump support. The LAP decreased from 21-23 to 17-19 mm Hg in all DHF conditions (difference not significant). Furthermore, hemodynamic parameters improved for all DHF conditions, independent of heart rate. The LAAD can provide adequate flow to maintain the circulation status at various heart rates in an in vitro mock circulatory loop.
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Kado et al. (2020) studied Heart failure with preserved ejection fraction (HFpEF). Left atrial assist device (LAAD) vs. non-pump support was evaluated on Hemodynamic effects (Cardiac output, mean aortic pressure, mean LA pressure) (p=not significant). Left atrial assist device support in a mock circulatory loop maintained adequate cardiac output (3.4-3.8 L/min) and aortic pressure (90-105 mm Hg) across various heart rates and diastolic heart failure conditions.
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