Key result
Chronic steroid therapy (median 5mg prednisolone for 9.5 years) was not associated with increased mortality or morbidity following cardiac surgery compared to matched controls.
Why the study?
Does chronic steroid therapy increase the risk of adverse post-operative outcomes in patients undergoing cardiac surgery?
Population
196 patients undergoing cardiac surgery
Comparison
Chronic steroid therapy vs Propensity-matched control group not on steroids
Design
Cohort
Follow-up
post-operative period
Authors
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May reassure on perioperative safety for steroid users; leaves open need for randomized confirmation.
Cohort (n=196)
No
Does chronic steroid therapy increase the risk of adverse post-operative outcomes in patients undergoing cardiac surgery?
Chronic steroid therapy prior to cardiac surgery does not appear to increase the risk of major post-operative mortality or morbidity.
Pai et al. (2005) conducted a cohort in Cardiac surgery (n=196). Chronic steroid therapy vs. No chronic steroid therapy was evaluated on Post-operative mortality and morbidity (stroke, renal failure, abdominal complications, wound infections, inotropic support, myocardial infarction). Chronic steroid therapy (median 5mg prednisolone for 9.5 years) was not associated with increased mortality or morbidity following cardiac surgery compared to matched controls.
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