Why the study?
Does aspirin pretreatment enhance the hemodynamic effects and plasma levels of sublingual nitroglycerin in healthy volunteers?
Population
7 healthy volunteers
Comparison
Nitroglycerin administered 1 hour after 1 g of… vs Nitroglycerin without aspirin pretreatment
Design
RCT, Random order (crossover design)
Follow-up
30 minutes after nitroglycerin administration
Authors
Loading...
May warrant caution with nitroglycerin coadministration in patients; confirms pharmacokinetic potentiation in this RCT.
Does aspirin pretreatment enhance the hemodynamic effects and plasma levels of sublingual nitroglycerin in healthy volunteers?
Pretreatment with high-dose aspirin increases nitroglycerin plasma levels and significantly enhances its hemodynamic effects, indicating a relevant pharmacokinetic interaction.
Weber et al. (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: