Key result
Platelet-leukocyte interactions play a key role in initiating inflammation and triggering autocrine and paracrine activation processes that lead to atherosclerosis.
This review highlights the molecular mechanisms by which platelet-leukocyte interactions contribute to vascular inflammation and atherothrombosis.
Supports research on modulating platelet-leukocyte interactions in atherosclerosis; leaves open whether this alters clinical outcomes.
Inflammatory processes at the vascular wall result in the development of atherosclerosis. Platelet interactions with leukocytes may play a key role in the initiation of inflammation. They trigger autocrine and paracrine activation processes, leading to leukocyte recruitment (in)to the vascular wall. This article highlights the molecular basis and the inflammatory pathways initiated by platelet-leukocyte interactions.
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May et al. (2007) conducted a review in Atherosclerosis and inflammation. Platelet-leukocyte interactions was evaluated. Platelet-leukocyte interactions play a key role in initiating inflammation and triggering autocrine and paracrine activation processes that lead to atherosclerosis.