Key result
Glyceryl trinitrate caused concentration-related vascular relaxation without increasing NO-related fluorescence or augmenting the Km for O2, unlike NO donors and acetylcholine.
Population
Rat aortic vascular wall and isolated rings of aorta
Comparison
Glyceryl trinitrate (GTN) vs NO donors and endothelial activation with…
Design
Preclinical
Authors
Loading...
Questions GTN mechanism as free NO release; leaves open alternative active species for further mechanistic study.
GTN induces vascular relaxation without releasing free NO or inhibiting mitochondrial oxygen consumption, suggesting its mechanism of action involves a different active species.
Núñez et al. (2005) studied this question. Glyceryl trinitrate (GTN) vs. NO donors and acetylcholine was evaluated on Intracellular levels of NO, vascular relaxation, and mitochondrial respiration. Glyceryl trinitrate caused concentration-related vascular relaxation without increasing NO-related fluorescence or augmenting the Km for O2, unlike NO donors and acetylcholine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: