Key result
In vitro, genuine NO donors show excellent correlation between sGC activation and NO release rates, whereas nitroglycerin acts as a partial agonist and may activate sGC via an NO-independent mechanism.
Population
In vitro biological systems (soluble guanylyl cyclase)
Comparison
Nitroglycerin and other organic nitrates vs Genuine NO donors (NONOates and nitrosothiols)
Design
Preclinical
Authors
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Questions nitroglycerin’s NO-dependent sGC activation; leaves open clinical relevance to tolerance or efficacy.
Nitroglycerin activates soluble guanylyl cyclase via an NO-independent mechanism and acts as a partial agonist compared to genuine NO donors.
Artz et al. (2001) studied this question. NO donors and NO mimetics (GTN) was evaluated on sGC activation and NO release. In vitro, genuine NO donors show excellent correlation between sGC activation and NO release rates, whereas nitroglycerin acts as a partial agonist and may activate sGC via an NO-independent mechanism.
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