Key result
Nitrolingual-Spray was as effective as nitroglycerin tablets in improving ischemic time (137.2 s vs 152.9 s; P=0.005) and ischemic burden, with fewer episodes of hypotension and headache.
Why the study?
Does nitroglycerin spray improve exercise time and ischemic parameters compared to nitroglycerin tablets in patients with coronary artery disease?
Population
28 patients with coronary artery disease and more than 50% stenosis in at least one major coronary artery
Comparison
Nitroglycerin spray vs Nitroglycerin tablets
Design
RCT, randomized crossover
Authors
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Supports nitroglycerin spray preference over tablets in CAD; confirms equivalent ischemic benefit with better tolerability in RCT.
RCT (n=28)
Crossover
Does nitroglycerin spray improve exercise time and ischemic parameters compared to nitroglycerin tablets in patients with coronary artery disease?
Absolute Event Rate: 137.2% vs 152.9%
p-value: p=0.005
Nitroglycerin spray is as effective as nitroglycerin tablets for improving ischemic parameters during exercise in CAD patients, but is associated with fewer episodes of hypotension and headache.
Chien et al. (2000) conducted an RCT in Coronary artery disease (n=28). Nitrolingual-Spray vs. Nitroglycerin (NTG) tablets was evaluated on Ischemic time (seconds) (p=0.005). Nitrolingual-Spray was as effective as nitroglycerin tablets in improving ischemic time (137.2 s vs 152.9 s; P=0.005) and ischemic burden, with fewer episodes of hypotension and headache.
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