Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1979Circulation

Dilatation of the ductus arteriosus by prostaglandin E1 in aortic arch abnormalities.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does prostaglandin E1 infusion dilate the ductus arteriosus and improve hemodynamics in infants with aortic arch abnormalities?

Population

15 infants (7 with aortic arch interruption and 8 with coarctation of the aorta)

Design

Case_series

Authors

MHMichaël HeymannUniversity of StuttgartWBWalter I. BermanUniversity of North TexasARAbraham M. RudolphBoston University

Discussion

Loading...

Member takes

Implication

May support PGE1 for stabilization in ductal-dependent aortic arch anomalies; leaves open prospective validation in larger cohorts.

Structured PICO

Does prostaglandin E1 infusion dilate the ductus arteriosus and improve hemodynamics in infants with aortic arch abnormalities?

P
Population
15 infants (7 with aortic arch interruption and 8 with coarctation of the aorta)
I
Intervention
Prostaglandin E1 (PGE1) infused at a rate of 0.05-0.1 microgram/kg/min
O
Outcome
Dilatation of the ductus arteriosus (evidenced by an increase in descending aortic blood pressures and a reduction in pressure gradients)surrogate

Prostaglandin E1 infusion effectively dilates the ductus arteriosus and improves systemic perfusion in infants with ductal-dependent aortic arch abnormalities.

Cite This Study

Heymann et al. (1979) studied this question.

synapsesocial.com/papers/6a9749f47ea32095d4ecb699https://doi.org/10.1161/01.cir.59.1.169
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Histopathology of the ductus arteriosus after prostaglandin E1 administration in ductus dependent cardiac anomalies.1978 · 61 citations
  2. 2Prolonged Prostaglandin E1 Infusion: Histologic Effects on the Patent Ductus Arteriosus1981 · 36 citations
  3. 3Use of prostaglandin E2 in management of transposition of great arteries before balloon atrial septostomy.1983 · 19 citations
  4. 4Closure of the Ductus Arteriosus in Premature Infants by Inhibition of Prostaglandin Synthesis1976 · 517 citations
  5. 5Effects of Phosphodiesterase-3 Inhibitor in the Management of Left Heart Failure in Extremely Low-Birth-Weight Infants with Simple Aortic Coarctation2025