Key result
Combined general anesthesia in women of reproductive age led to the development of cognitive dysfunction, increased depression, and reduced memory and attention compared to baseline.
Why the study?
Depression and cognitive dysfunction in the postoperative period may be associated with pregnancy, surgery, and type of anesthetic support.
Does combined general anesthesia compared to regional anesthesia worsen cognitive functions, memory, and attention in pregnant and non-pregnant women of reproductive age?
Observational (n=120)
Yes
Does combined general anesthesia compared to regional anesthesia worsen cognitive functions, memory, and attention in pregnant and non-pregnant women of reproductive age?
Absolute Event Rate: 24.2% vs 25.2%
p-value: p=<0.004
Combined general anesthesia in women of reproductive age leads to a greater decline in cognitive function, memory, and attention in the early postoperative period compared to regional anesthesia.
General anesthesia was associated with greater early cognitive decline than regional anesthesia; hypothesis-generating and should not yet change practice.
BACKGROUND: Depression and cognitive dysfunction in the postoperative period may be associated with pregnancy, surgery, and type of anesthetic support. OBJECTIVE: To perform a comparative assessment of the effect of combined general and regional anesthesia on memory and attention in pregnant and nonpregnant women. MATERIALS AND METHODS: The study involved 120 women of reproductive age who were admitted for surgery. According to the indications, they received various anesthesia types depending on their somatic status. The cognitive potential of the patients and indicators of memory and attention, anxiety, and depression were evaluated using specially selected tests before surgery and three days after surgery. The effect of anesthesia on pregnant women during planned operative delivery was studied, and planned interventions in gynecology were used for comparison. RESULTS: The MOS test scores in all groups were reduced, and they indicated a reduced cognitive potential in nonpregnant women [26.2 (26.9; 25.5) and 24 (24.59; 23.44)] under general anesthesia (p 0.003) and pregnant women [25.2 (25.7; 24.7) and 24.6 (25.36; 23.84)] under general anesthesia (p 0.004). After the operation under OA, the results worsened, and statistical differences were revealed. The level of attention in pregnant women decreased according to the results of the Wexler test after surgery in the general anesthesia group [4.5 (5.1; 3.9) and 3 (3.46; 2.54), p 0.006], and in the regional anesthesia group, the results decreased but to a lesser extent degree [5 (5.8; 4.2) and 3.5 (4.2; 2.8, p 0.005], showing statistical difference. According to the results of the Benton test after surgery in the general anesthesia group, visual short-term memory decreased in pregnant women [6.15 (6.75; 5.55) and 4 (4.86; 3.14), p 0.002], and in the regional anesthesia group, the results decreased, but to a lesser extent [6.2 (6.9; 5.5) and 4.5 (5.2; 3.8, p 0.012], and statistical differences were noted. CONCLUSION: The effect of combined general and regional anesthesia led to the development of cognitive dysfunction, increased depression, and changes in memory and attention.
No takes yet. Share an insight, caveat, or question.
Chernykh et al. (2023) conducted an observational in Women of reproductive age undergoing planned surgery (n=120). Combined general anesthesia vs. Regional anesthesia was evaluated on MoCA test score in pregnant women (3 days post-general anesthesia vs baseline) (p=<0.004). Combined general anesthesia in women of reproductive age led to the development of cognitive dysfunction, increased depression, and reduced memory and attention compared to baseline.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: