Key result
Increasing BMI was associated with a progressively blunted systolic blood pressure response to angiotensin II in overweight men (P=0.007), but not in women.
Why the study?
Does sex influence the effect of body mass index on the vascular response to angiotensin II in healthy humans?
Cross-Sectional (n=43)
Does sex influence the effect of body mass index on the vascular response to angiotensin II in healthy humans?
Sex modifies the relationship between adiposity and vascular responsiveness to angiotensin II, with overweight men showing a blunted response not seen in women.
Should not yet change hypertension management; leaves open sex-specific effects of adiposity on angiotensin II responsiveness for prospective validation.
OBJECTIVE: Sex influences the cardiorenal risk associated with body mass index (BMI). The role of the renin-angiotensin-aldosterone system in adiposity-mediated cardiorenal risk profiles in healthy, non-obese men and women was investigated. METHODS: Systemic and renal hemodynamic responses to angiotensin-II (AngII) as a function of BMI, waist and hip circumference, waist-hip ratio, as well as fat and lean mass were measured in 18 men and 25 women in high-salt balance, stratified by BMI (<25 kg/m2 (ideal body weight (IBW)) vs. ≥25 kg/m2 overweight)). RESULTS: In men (n = 7, BMI 23 ± 1 kg/m2) and women (n = 14, BMI 22 ± 2 kg/m2) of IBW, BMI was not associated with the systolic blood pressure (SBP) response to AngII. In contrast, overweight men (n = 11, 29 ± 2 kg/m2) demonstrated a progressively more blunted vasoconstrictor SBP response to AngII challenge as BMI increased (P = 0.007), even after adjustment for covariates. Women maintained the same relationship between BMI and the SBP response to AngII irrespective of weight status (P = 0.2, IBW vs. overweight women). Compared to BMI, other adiposity measures showed similar associations to systemic AngII responsiveness in men but not in women. Increasing BMI was associated with a blunted renovasoconstrictor response to AngII in all subjects, but was more pronounced in men. CONCLUSION: Sex influences the effect of adiposity on vascular angiotensin-responsiveness.
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Zalucky et al. (2013) conducted a cross-sectional in Healthy adults (n=43). Body mass index (BMI) vs. Ideal body weight (<25 kg/m2) was evaluated on Systemic and renal hemodynamic responses to angiotensin-II (AngII) (p=0.007). Increasing BMI was associated with a progressively blunted systolic blood pressure response to angiotensin II in overweight men (P=0.007), but not in women.
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