Key result
A 5-unit increment in body mass index was associated with a 17% decreased risk of mortality among patients with pulmonary hypertension (RR 0.83).
Why the study?
The shape and strength of the dose-response association between body mass index and mortality among pulmonary hypertension patients needed clarification.
Does higher BMI reduce mortality in pulmonary hypertension patients?
Meta-Analysis (n=127,215)
Does higher BMI reduce mortality in pulmonary hypertension patients?
Relative Risk: 0.83 (95% CI 0.77–0.89)
p-value: p=<0.001
Higher BMI is associated with a decreased risk of mortality among pulmonary hypertension patients, with the lowest risk observed at a BMI of 32-38 kg/m2, highlighting an 'obesity paradox' in this population.
Supports obesity paradox in PH but should not yet change practice; leaves open causal effects and optimal targets.
Objective To run a systematic review and meta-analysis of related studies on body mass index (BMI) and the risk of death among pulmonary hypertension (PH) patients, as well as, to shed light on the shape and strength of the dose-response association. Methods Studies published up to Jun 2021 in scientific databases such as Scopus, and PubMed as well as Google Scholar were searched. Cohort studies that reported risk estimates for at least two categories of BMI or per certain increase in BMI in relation to mortality in PH patients were included. Summary relative risks were determined with random effects models. Non-linear relationship was discovered with dose-response analysis. Results All in all, 15 cohort studies were selected. The number of participants was 127,215 out of which 73,999 were reported dead. The summary RR for mortality per a 5-unit increment in BMI was 0.83 (95% confidence interval 0.77–0.89; I2 = 75.6%, n = 9) among PH patients. There was a non-linear dose-response relation between BMI and mortality in PH patients (Pnon−linearity < 0.001), with the lowest risk being at BMI 32–38 kg/m2. Conclusion Higher BMI is related to decreased risk of mortality among PH patients and the lowest point of the curve was seen at BMI 32–38.
No takes yet. Share an insight, caveat, or question.
Jiang et al. (2022) conducted a meta-analysis in Pulmonary hypertension (n=127,215). Body mass index vs. Lower body mass index was evaluated on Mortality (RR 0.83, 95% CI 0.77-0.89, p=<0.001). A 5-unit increment in body mass index was associated with a 17% decreased risk of mortality among patients with pulmonary hypertension (RR 0.83).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: