Key result
Mid-regional pro-atrial natriuretic peptide (MR-proANP) levels were significantly higher in patients with acute pulmonary embolism compared to controls (645.8 vs 442.9 pmol/L, p=0.003).
Why the study?
Right ventricular failure can develop in pulmonary embolism and increases mortality, but the diagnostic value of MR-proANP in emergency department patients with suspected PE needed investigation.
Does MR-proANP level help diagnose acute pulmonary embolism in patients presenting to the emergency department?
Case-Control (n=150)
No
Does MR-proANP level help diagnose acute pulmonary embolism in patients presenting to the emergency department?
MR-proANP levels are significantly elevated in patients with acute pulmonary embolism and may serve as a useful biomarker to improve diagnostic accuracy in the emergency department.
MR-proANP elevation was associated with acute PE; leaves open diagnostic utility in the ED pending prospective validation.
Aim: Right ventricular failure can develop in patients with pulmonary embolism (PE) and is associated with increased mortality. Mid-regional pro-atrial natriuretic peptide (MR-proANP), a natriuretic peptide, is secreted due to the increased atrial wall tension caused by right heart failure. In this study, we aimed to investigate the diagnostic value of MR-proANP in patients who presented to the emergency department with a pre-diagnosis of pulmonary embolism. Material and Methods: Among patients with a preliminary diagnosis of PE, 100 patients who were confirmed to have PE by computed tomography pulmonary angiography (CTPA) were determined as the case group. As a control group, 50 patients were randomly identified, in whom the diagnosis of PE was excluded. Echocardiography was performed in all patients in the case group immediately after the diagnosis was confirmed, and the presence of right ventricular dysfunction was investigated. This study was designed as a prospective observational study. Results: The median value of ) pmol/L) in the case group was found to be significantly higher than median value of ) pmol/L) in the control group (p:0.003). MR-proANP was found to be significantly higher in the differential diagnosis of PE. Discussion: In addition to clinical signs and symptoms, MR-proANP levels seem to be a useful variable that may improve diagnostic accuracy in patients with suspected pulmonary embolism in the emergency department.
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Altuğ et al. (2023) conducted a case-control in Acute pulmonary embolism (n=150). Mid-regional pro-atrial natriuretic peptide (MR-proANP) vs. Patients without pulmonary embolism was evaluated on Median MR-proANP level (pmol/L) (p=0.003). Mid-regional pro-atrial natriuretic peptide (MR-proANP) levels were significantly higher in patients with acute pulmonary embolism compared to controls (645.8 vs 442.9 pmol/L, p=0.003).
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