Key result
Intravenous amiodarone and oral bethanidine prolonged the stimulus-peak evoked T wave interval by an average of 39.4 ms and 25.8 ms, respectively, compared to control values.
Why the study?
Does the paced evoked response system accurately assess drug-induced changes in myocardial repolarisation from amiodarone and bethanidine?
Comparison
Intravenous amiodarone and oral bethanidine vs Control values
Design
Other
Follow-up
3 hours (for bethanidine)
Authors
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Supports paced evoked response for assessing class III repolarization effects; extends validation but remains hypothesis-generating pending larger trials.
Does the paced evoked response system accurately assess drug-induced changes in myocardial repolarisation from amiodarone and bethanidine?
Mean Difference: 39.4
The paced evoked response system provides a simple and accurate method for assessing the effects of class III antiarrhythmic drugs on cellular action potential duration.
Donaldson et al. (1982) studied this question. Intravenous amiodarone and oral bethanidine vs. Control values (before drug administration) was evaluated on Stimulus-peak evoked T wave interval (MD 39.4 ms (amiodarone) and 25.8 ms (bethanidine)). Intravenous amiodarone and oral bethanidine prolonged the stimulus-peak evoked T wave interval by an average of 39.4 ms and 25.8 ms, respectively, compared to control values.
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