Key result
Bail-out edge-to-edge mitral valve repair with three MitraClip XTR devices successfully stabilized an initial single-leaflet detachment and improved symptoms in a patient with Marfan syndrome at 10 months.
Why the study?
Mitral valve prolapse with subsequent severe MR is a common manifestation of Marfan syndrome, but MTEER had never been reported as a treatment option in these patients.
Case Report (n=1)
No
MTEER is a feasible bail-out option for severe mitral regurgitation in patients with Marfan syndrome and high surgical risk, though operators must be prepared for a higher risk of device detachment due to tissue characteristics.
May support MTEER bailout in high-risk Marfan patients; hypothesis-generating for detachment risk and durability.
Mitral transcatheter edge-to-edge repair (MTEER) is the first transcatheter technique for mitral valve repair (MVR) in patients with severe mitral regurgitation (MR) who are considered at high risk for surgical intervention. Mitral valve prolapse with subsequent MR is a common manifestation of Marfan syndrome. MTEER has never been reported as a treatment option in such kind of patients. We describe the case of a 30-year-old patient who was known to have Marfan syndrome which was complicated with severe symptomatic MR. The surgical risk was high, and he preferred transcatheter intervention. MTEER was complicated with an immediate single-leaflet detachment of the first deployed MitraClip XTR. Bail-out edge-to-edge MVR with two additional MitraClip XTR was performed successfully to stabilize the detached clip. The patient's symptoms and quality of life improved significantly after 10 months of follow-up.
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Alzaeem et al. (2022) conducted a case report in Marfan syndrome with severe mitral regurgitation (n=1). Mitral transcatheter edge-to-edge repair (MTEER) using MitraClip was evaluated on Procedural success and symptom improvement. Bail-out edge-to-edge mitral valve repair with three MitraClip XTR devices successfully stabilized an initial single-leaflet detachment and improved symptoms in a patient with Marfan syndrome at 10 months.
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