Key result
A newly reported comparative method evaluates murine studies of single gene defects to determine their impact on thrombosis and bleeding in comparison with human orthologs.
Highlights a new methodological approach to compare murine genetic thrombosis and bleeding studies with human orthologs.
In this issue of Blood, Baaten et al report a new method of comparing published murine studies assessing the impact of single gene defects on arterial thrombus formation, thromboembolism, and tail bleeding time. This approach is meant to obtain reliable information on the role of specific genes in thrombosis and hemorrhage in comparison with human orthologs.1
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Gresele et al. (2018) studied this question. A newly reported comparative method evaluates murine studies of single gene defects to determine their impact on thrombosis and bleeding in comparison with human orthologs.
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