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February 7, 2005Circulation

Magnetic Resonance Imaging Predictors of Coarctation Severity

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Key result

The combination of MRI-derived anatomic and flow data predicted a catheterization gradient ≥20 mm Hg with 95% sensitivity, 82% specificity, and an AUC of 0.938.

Why the study?

Does MRI accurately predict a transcatheter pressure gradient >=20 mm Hg in patients with aortic coarctation?

Population

31 subjects referred for assessment of native or recurrent aortic coarctation, excluding those with cardiac…

Comparison

Magnetic Resonance Imaging vs Cardiac catheterization (reference standard)

Design

Cohort

Authors

JNJames C. NielsenAPAndrew J. PowellKGKimberlee Gauvreau

Discussion

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Overview

The combination of anatomic and flow data from MRI provides a highly sensitive and specific non-invasive method to predict clinically significant aortic coarctation gradients.

Study Design

Type

Observational (n=41)

Structured PICO

Does MRI accurately predict a transcatheter pressure gradient >=20 mm Hg in patients with aortic coarctation?

P
Population
41 patients (31 in derivation cohort, 10 in validation cohort) referred for assessment of native or recurrent aortic coarctation.
E
Exposure
Magnetic Resonance Imaging (gadolinium-enhanced 3D MRA and phase-velocity cine MRI)
C
Comparator
Cardiac catheterization (reference standard)
O
Outcome
Prediction of peak coarctation gradient >=20 mm Hg by catheterizationsurrogate

Main Result

Odds Ratio: 1.71

p-value: p=0.005

The combination of anatomic and flow data from MRI provides a highly sensitive and specific non-invasive method to predict clinically significant aortic coarctation gradients.

Cite This Study

Nielsen et al. (2005) conducted an observational in Aortic coarctation (n=41). Magnetic Resonance Imaging (MRI) vs. Cardiac catheterization was evaluated on Peak coarctation gradient >= 20 mm Hg by catheterization (OR 1.71, p=0.005). The combination of MRI-derived anatomic and flow data predicted a catheterization gradient ≥20 mm Hg with 95% sensitivity, 82% specificity, and an AUC of 0.938.

synapsesocial.com/papers/6a975a0ccfa25b768ec60b3ahttps://doi.org/10.1161/01.cir.0000154549.53684.64
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thoracic aorta: comparison of gadolinium-enhanced three-dimensional MR angiography with conventional MR imaging.1997 · 201 citations
  2. 2Collateral flow in coarctation of the aorta with magnetic resonance velocity mapping: Correlation to morphological imaging of collateral vessels2002 · 54 citations