Study of the Resistance Pattern of Antimicrobials Used in Septicemia Patients in a Tertiary Care Teaching Hospital

Background: Globally, the development of Antimicrobial Resistance (AMR) in pathogen-causing infectious disease is a great public health concern, including our country, and is the main challenge for the physician. The present study was conducted to assess the current status of the resistance pattern of currently used antimicrobial agents in the setting of septicemia. Method: 384 Patients with Septicemia who met the study criteria, with Microorganism positive blood samples were included in this study. The study was conducted in Pt JNM Medical College Raipur and Dr. B.R.A.M. Hospital during the year of 2017-2019). It was a Prospective, Observational Study. Result: The majority of patients were newborn 210 (54.7%), Out of 384 patients, 244 were males (63.54%) and 140 were females (36.46%). In our study, the predominant bacteria isolated from blood Culture was Coagulase-Negative Staphylococcus (CONS) 139(36.2%), followed by Klebsiella pneumoniae 48 (12.5%). The Gram-positive and Gram-negative bacteria constituted 183(47.7 %) and 161(41.9%) respectively, Coagulase-negative staph aureus (CONS) was most sensitive to Vancomycin (89.2%) & high resistance to Ampicillin (88.5%), followed by Penicillin-G (86.33%).