Key result
Raising perfusion pressure from 5 to 20 mm Hg in rabbit jugular veins caused a profound, time-dependent, transcription-level increase in prepro-ET-1 and endothelin B receptor expression.
Why the study?
Does increased intraluminal pressure upregulate ET-1 and endothelin B receptor expression in rabbit jugular veins?
Population
Isolated segments of the rabbit jugular vein
Comparison
Nonphysiological level of intraluminal pressure… vs Physiological level of intraluminal pressure
Design
Preclinical
Follow-up
up to 12 hours
Authors
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Hypothesis-generating for pressure-driven ET-1 signaling in vein graft failure; human studies required before any clinical consideration.
Does increased intraluminal pressure upregulate ET-1 and endothelin B receptor expression in rabbit jugular veins?
Increased intraluminal pressure upregulates ET-1 and endothelin B receptor expression in rabbit jugular veins, suggesting a mechanism for venous bypass graft failure.
Lauth et al. (2000) studied Venous bypass graft failure model. Nonphysiological intraluminal pressure (20 mm Hg) vs. Physiological intraluminal pressure (0 to 5 mm Hg) was evaluated on Expression of prepro-ET-1 mRNA, intravascular ET-1 abundance, and smooth muscle endothelin B receptor mRNA and functional protein. Raising perfusion pressure from 5 to 20 mm Hg in rabbit jugular veins caused a profound, time-dependent, transcription-level increase in prepro-ET-1 and endothelin B receptor expression.
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