Key result
Patients with mitral stenosis frequently exhibit extensive structural changes in the lungs and moderate deviations in pulmonary function, with unclear clinical implications.
This historical paper discusses the structural and functional pulmonary changes associated with mitral stenosis.
Pulmonary monitoring may be considered in mitral stenosis; leaves open whether structural changes predict outcomes or warrant intervention.
Article1 December 1958SOME ASPECTS OF DISORDERED PULMONARY FUNCTION IN MITRAL STENOSISD. J. MACINTOSH, M.D., J. C. SINNOTT, M.D., I. G. MILNE, M.D., E. A. S. REID, M.D., F.A.C.P.D. J. MACINTOSH, M.D., J. C. SINNOTT, M.D., I. G. MILNE, M.D., E. A. S. REID, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-6-1294 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with mitral stenosis frequently exhibit extensive structural changes in the lungs as a result of that disease.1, 2 All components of the pulmonary vascular bed may be affected to variable degrees, and alterations of an edematous and fibrotic nature are commonly observed in the alveolar membrane.The extent to which these pulmonary changes influence the clinical picture in mitral stenosis is not clear. The studies of pulmonary function reported in the literature3, 4, 5, 7, 13show moderate deviations from the normal but have contributed little either to a basic understanding of the disease or to the clinical management...Bibliography1. ParkerWeiss FS: The nature and significance of the structural changes in the lungs in mitral stenosis, Am. J. Path. 12: 573, 1936. MedlineGoogle Scholar2. LarabeeParkerEdwards WFRFJF: Pathology of intrapulmonary arteries and arterioles in mitral stenosis, Proc. Staff Meet., Mayo Clin. 24: 316, 1949. MedlineGoogle Scholar3. Scott RC: Pulmonary function in mitral stenosis: a review of current concepts, Ann. Int. Med. 41: 980, 1954. LinkGoogle Scholar4. DraperHeimbeckerDaleyCarrollMuddWellsFalholtAndrusBing ARRDGRWECRJ: Physiologic studies in mitral valvular disease, Circulation 3: 531, 1951. CrossrefMedlineGoogle Scholar5. 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HendersonHaggard YHW: The circulation and its measurement, Am. J. Physiol. 73: 193, 1925. CrossrefGoogle Scholar12. Nomenclature and Criteria for Diagnosis of Diseases of the Heart, New York Heart Association, 1939. Google Scholar13. RileyJohnsCohenCohnCarrollShepard RLCJGJEDGRH: The diffusing capacity of the lungs in patients with mitral stenosis studied postoperatively, J. Clin. Investigation 35: 1008, 1956. CrossrefMedlineGoogle Scholar14. FerrerHarveyWylieHimmelsteinLambertKushnerCournandRichards MIRMRHAAMADW: Circulatory effects of mitral commissurotomy with particular reference to selection of patients for surgery, Circulation 12: 7, 1955. CrossrefMedlineGoogle Scholar15. JudsonHatcherHollanderHalperin WEJDWMH: The effects of mitral valvuloplasty on cardiovascular and renal function at rest and during exercise, J. Clin. Investigation 34: 1297, 1955. CrossrefMedlineGoogle Scholar16. LevConnollyKirklinWood RDCJEH: The immediate hemodynamic effects of mitral commissurotomy during surgery, S. Forum 4: 13, 1953. MedlineGoogle Scholar17. SaxtonRabinowitzDexterHaynes GAMLF: The relationship of pulmonary compliance to pulmonary vascular pressures in patients with heart disease, J. Clin. Investigation 34: 611, 1956. CrossrefGoogle Scholar18. PryorHickamSeikerPage WWJBHLEB: Effect of circulatory changes on the pulmonary compliance of normal subjects and patients with mitral stenosis, Circulation 15: 721, 1957. CrossrefMedlineGoogle Scholar19. HaywardKnott GWJM: The effect of exercise on lung distensibility and respiratory work in mitral stenosis, Brit. Heart J. 17: 303, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal,*Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 1, 1958.From the McGill University Clinic and Cardio-Respiratory Subdepartment of the Department of Medicine, The Montreal General Hospital, Montreal, Canada.†This study was supported in part by a research grant from the Cooper Fund, McGill University.‡Sir Edward Beatty Research Fellow, McGill University.Requests for reprints should be addressed to D. J. MacIntosh, M.D., Director, Cardio-Respiratory Laboratory, The Montreal General Hospital, 1650 Cedar Avenue, Montreal 25, Canada. 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Macintosh et al. (1958) studied Mitral stenosis. Patients with mitral stenosis frequently exhibit extensive structural changes in the lungs and moderate deviations in pulmonary function, with unclear clinical implications.
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