Key result
A multimodality imaging approach including real-time three-dimensional contrast-enhanced echocardiography characterizes Löeffler disease complicated by thrombus formation and neoangiogenesis.
Case Report
Real-time three-dimensional contrast-enhanced echocardiography and multimodality imaging can be effectively utilized for the diagnosis and follow-up of Löeffler eosinophilic myocarditis.
May aid diagnosis and follow-up in Loeffler myocarditis; leaves open prospective validation of 3D contrast echo.
Löeffler endocarditis is a rare myocardial disease often due to eosinophil leukemia or idiopathic hypereosinophilic syndrome. Degranulation of eosinophils within the eosinophil infiltrated myocardium is associated with myocardial necrosis due to the release of toxic cationic proteins, and with mural thrombi formation, which can occur anywhere in the ventricles. Thrombus formed on denuded myocardium is replaced by fibrosis as the final pathological stage of the disease, eventually leading to restrictive cardiomyopathy. We describe a multimodality imaging approach to the diagnosis and follow-up evaluation of Löeffler disease complicated by thrombus formation and neoangiogenesis of LV apex.
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Bene et al. (2011) conducted a case report in Löeffler Eosinophilic Myocarditis. Real Time Three-Dimensional Contrast-Enhanced Echocardiography was evaluated. A multimodality imaging approach including real-time three-dimensional contrast-enhanced echocardiography characterizes Löeffler disease complicated by thrombus formation and neoangiogenesis.
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