Intraperitoneal inoculation of murine adenovirus in newborn mice induces viral endocarditis, demonstrating direct viral infection of heart valves.
Newborn mice offer a model for studying viral endocarditis; human translation and therapeutic relevance remain to be tested.
Viral endocarditis developed in 24 percent of 50 newborn mice 6 to 8 days after intraperitoneal inoculation with murine adenovirus. Typical adenovirus intranuclear inclusions were seen in heart-valve lesions, and high titers of virus were recovered from heart tissue. Furthermore, adenovirions were directly visualized by electron microscopy within endothelial cells and fibroblasts of the heart valves.
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Blailock et al. (1967) studied this question.
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