Key result
A two-week very-low-calorie diet decreased body weight, improved metabolic profile, and reduced mRNA expression of up-regulated chemokine receptors in peripheral monocytes of obese T2DM patients.
Why the study?
Does a very-low-calorie diet improve the expression profile of inflammation-related genes in subcutaneous adipose tissue and peripheral monocytes of obese patients with T2DM?
Population
35 females, including 12 obese with type 2 diabetes mellitus, 8 obese nondiabetic, and 15 healthy…
Comparison
Two weeks of very-low-calorie diet. vs Baseline values and healthy/obese non-diabetic…
Design
Cohort
Follow-up
2 weeks
Authors
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Short-term very-low-calorie diet was associated with reduced monocyte chemokine receptor expression in obese T2DM; hypothesis-generating, does not yet warrant practice change.
Does a very-low-calorie diet improve the expression profile of inflammation-related genes in subcutaneous adipose tissue and peripheral monocytes of obese patients with T2DM?
A two-week very-low-calorie diet improves the proinflammatory and chemotactic gene expression profile in subcutaneous adipose tissue and peripheral monocytes of obese patients with T2DM.
Mráz et al. (2011) studied Obesity and Type 2 Diabetes Mellitus (n=35). Very-low-calorie diet (VLCD) vs. Baseline and healthy/obese nondiabetic controls was evaluated on Metabolic parameters, circulating cytokines, hormones, and mRNA expression of 39 genes in subcutaneous adipose tissue and peripheral monocytes. A two-week very-low-calorie diet decreased body weight, improved metabolic profile, and reduced mRNA expression of up-regulated chemokine receptors in peripheral monocytes of obese T2DM patients.
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