Key result
Continuous therapeutic ultrasound at 1 MHz increased forearm blood flow 5 minutes post-intervention compared to placebo (2.96 vs. 2.09 mL/min/100 mL, p<0.05).
Why the study?
Does 1 MHz therapeutic ultrasound improve forearm blood flow and microvascular reactivity in young, healthy individuals?
RCT (n=10)
Double-blind
cross-over
Does 1 MHz therapeutic ultrasound improve forearm blood flow and microvascular reactivity in young, healthy individuals?
Absolute Event Rate: 2.96% vs 2.09%
p-value: p=<0.05
Continuous therapeutic ultrasound at 1 MHz effectively increases forearm blood flow up to 5 minutes post-intervention in healthy individuals.
No immediate clinical application in patients; extends vascular mechanism data for therapeutic ultrasound trials in disease states.
A randomized, double-blind, placebo-controlled, cross-over study where continuous therapeutic ultrasound (CUS; at 0.4 W/cm2), pulsed therapeutic ultrasound (PUS; at 20% duty cycle, 0.08 W/cm2), both at 1 MHz, and placebo (equipment on, no energy provided) were randomized and applied over the forearm of the non-dominant arm for 5 min in 10 young, healthy individuals. Absolute and peak forearm blood flow (FBF) were measured via Venous Occlusion Plethysmography. FBF was measured before, halfway, and after (immediately and 5 min after) the therapeutic ultrasound (TUS) intervention. Post-ischemic peak FBF was measured 10 min before and 10 min after the TUS intervention. A two-way repeated measures ANOVA (group × time) was selected to assess differences in FBF before, during, and after TUS treatment, and for peak FBF before and after TUS treatment. FBF increased 5 min after TUS in CUS compared to placebo (2.96 ± 1.04 vs. 2.09 ± 0.63 mL/min/100 mL of tissue, p < 0.05). PUS resulted in the greatest increase in Peak FBF at 10 min after US (Δ = 3.96 ± 2.02 mL/min/100 mL of tissue, p = 0.06). CUS at 1 MHz was an effective treatment modality for increasing FBF up to 5 min after intervention, but PUS resulted in the greatest increase in peak FBF at 10 min after intervention.
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Waters et al. (2021) conducted an RCT in Healthy (n=10). Continuous and pulsed therapeutic ultrasound vs. Placebo was evaluated on Forearm blood flow (FBF) 5 min after intervention (p=<0.05). Continuous therapeutic ultrasound at 1 MHz increased forearm blood flow 5 minutes post-intervention compared to placebo (2.96 vs. 2.09 mL/min/100 mL, p<0.05).
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