Population
Embryonic chick ventricular hearts from the 4th, 6th, 12th, and 18th incubation days
Comparison
Developmental progression and tetrodotoxin… vs Different incubation days (4th, 6th vs 12th, 18th)
Design
Preclinical
Authors
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Animal data indicate conserved sodium channel properties during embryonic development; leaves open translation to human cardiac maturation or therapy.
The physicochemical properties of the sodium conductance unit and its TTX binding site remain constant during embryonic development despite a significant increase in maximal sodium conductance.
Iijima et al. (1979) studied this question.
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