Key result
Varying extracellular sodium and potassium concentrations in embryonic chick hearts showed that resting potential depends on potassium, while action potential amplitude and rate depend on sodium.
Population
Hearts isolated from 6-day and 19-day chick embryos
Design
Preclinical
Authors
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Chick embryo data leave open translation to human electrophysiology; hypothesis-generating for ion-dependent mechanisms in mammalian hearts.
The resting and action potentials in embryonic chick hearts depend primarily on extracellular potassium and sodium concentrations, respectively, despite high intracellular sodium levels.
Yeh et al. (1968) studied Embryonic cardiac muscle electrical activity. Varying extracellular sodium and potassium concentrations was evaluated on Transmembrane resting and action potentials. Varying extracellular sodium and potassium concentrations in embryonic chick hearts showed that resting potential depends on potassium, while action potential amplitude and rate depend on sodium.
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