Key result
Varying extracellular sodium and potassium concentrations in embryonic chick hearts showed that resting potential depends on potassium, while action potential amplitude and rate depend on sodium.
Population
Hearts isolated from 6-day and 19-day chick embryos
Design
Preclinical
Authors
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Does not warrant clinical changes; leaves open translational relevance of potassium-sodium dependence to mammalian embryos.
The study establishes that despite high intracellular sodium in early embryonic stages, the resting and action potentials in embryonic chick hearts are primarily driven by extracellular potassium and sodium concentrations, respectively.
Yeh et al. (1968) studied Embryonic chick hearts. Varying extracellular sodium and potassium concentrations was evaluated on Transmembrane resting and action potentials. Varying extracellular sodium and potassium concentrations in embryonic chick hearts showed that resting potential depends on potassium, while action potential amplitude and rate depend on sodium.
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