Key result
Obesity-induced adipocytes inhibit insulin secretion and promote apoptosis in pancreatic beta-cells by transferring exosomal miR-138-5p, which directly targets and downregulates SOX4.
Why the study?
Obesity is closely linked to islet dysfunction, but the underlying mechanisms remained unclear, and more effective clinical treatments for diabetes mellitus are needed.
Obesity-induced adipocyte exosomes containing miR-138-5p inhibit insulin secretion and promote beta-cell apoptosis via the SOX4-mediated Wnt/β-catenin pathway, offering a potential therapeutic target for obesity-related diabetes.
No takes yet. Share an insight, caveat, or question.
Should not yet change diabetes management; leaves open whether miR-138-5p targeting improves beta-cell function in vivo.
Fan et al. (2025) studied Type 1 diabetes mellitus and obesity. Exosomal miR-138-5p vs. Control / Negative control was evaluated on Insulin secretion and beta-cell apoptosis. Obesity-induced adipocytes inhibit insulin secretion and promote apoptosis in pancreatic beta-cells by transferring exosomal miR-138-5p, which directly targets and downregulates SOX4.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: