Key result
A novel cardiac electrogram acquisition and stimulation integrated circuit achieved a power supply rejection ratio of 80 dB and a common-mode rejection ratio of 174 dB in a swine right ventricle.
The proposed integrated circuit with a novel current-feedback instrumentation amplifier demonstrates high noise-power efficiency and high input impedance for leadless pacemaker applications in a swine model.
Promising ECG specs in swine support leadless pacemaker IC development; leaves open human translation pending clinical trials.
This paper proposes a cardiac electrogram acquisition and stimulation integrated circuit (IC) for single-chamber leadless pacemaker applications. The proposed IC features self-determining pacing by acquiring an intracardiac electrogram without an external digital signal processor (DSP). A novel current-feedback instrumentation amplifier (CFIA) is proposed to achieve high noise-power efficiency and high input impedance. In this proposed CFIA, the current-reused cascode differential-difference input stage and class-AB biasing stage are merged. The electrocardiogram (ECG) sensing channel, equipped with a 60-Hz notch filter to relieve powerline interference (PLI), achieves a power supply rejection ratio (PSRR) of 80 dB, a common-mode rejection ratio (CMRR) of 174 dB, and an input-referred noise of 3.47 μVRMS, in a 350 Hz bandwidth. The ECG acquisition and cardiac pacing functionality of the IC are evaluated in a swine's right ventricle via a 4-electrode catheter.
No takes yet. Share an insight, caveat, or question.
Choi et al. (2021) studied single-chamber leadless pacemaker applications. cardiac electrogram acquisition and stimulation integrated circuit (IC) with current-feedback instrumentation amplifier was evaluated on ECG sensing channel performance (PSRR, CMRR, input-referred noise). A novel cardiac electrogram acquisition and stimulation integrated circuit achieved a power supply rejection ratio of 80 dB and a common-mode rejection ratio of 174 dB in a swine right ventricle.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: