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October 22, 2022CureusOpen Access

Global Longitudinal Strain as an Efficient Prognostic Tool in Hypertrophic Cardiomyopathy With Preserved Left Ventricular Ejection Fraction

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Key result

In a patient with hypertrophic cardiomyopathy and preserved ejection fraction, a markedly impaired global longitudinal strain of -6.2% guided the decision to initiate anticoagulation.

Why the study?

The authors intended to demonstrate the clinical utility of global longitudinal strain in patients with hypertrophic cardiomyopathy and preserved ejection fraction.

Population

One 54-year-old female presenting with new-onset atrial fibrillation, HCM, and preserved ejection fraction

Design

Case report

Authors

OBOwen BattelKNKevin NewsomeMontefiore Medical CenterGIGuillermo Izquierdo-PretelUniversidad del Desarrollo

Discussion

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Member takes

Overview

GLS may aid evaluation in HCM with preserved EF; hypothesis-generating and requires prospective validation before practice change.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
A 54-year-old female with hypertrophic cardiomyopathy, preserved ejection fraction, and new-onset atrial fibrillation.
E
Exposure
Global longitudinal strain (GLS) measurement via speckle tracking echocardiography to guide clinical management (anticoagulation).

Global longitudinal strain may serve as a useful prognostic tool to detect subtle left ventricular dysfunction and guide anticoagulation in patients with hypertrophic cardiomyopathy and atrial fibrillation who have preserved ejection fraction.

Limitations

  • Single case report limits generalizability
  • Lack of consensus regarding what value of GLS should prompt a physician to alter care

Cite This Study

Battel et al. (2022) conducted a case report in Hypertrophic cardiomyopathy with preserved left ventricular ejection fraction (n=1). Global longitudinal strain (GLS) measurement was evaluated. In a patient with hypertrophic cardiomyopathy and preserved ejection fraction, a markedly impaired global longitudinal strain of -6.2% guided the decision to initiate anticoagulation.

synapsesocial.com/papers/6a977d1ad08ffd74dfc61597https://doi.org/10.7759/cureus.30573
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial fibrillation per se was a major determinant of global left ventricular longitudinal systolic strain2016 · 17 citations
  2. 2Global Longitudinal Strain Corrected by RR Interval is a Superior Predictor of All-Cause Mortality in Patients with Systolic Heart Failure and Atrial Fibrillation2017 · 25 citations
  3. 3Left Ventricular Systolic Function Assessed by Global Longitudinal Strain is Impaired in Atrial Fibrillation Compared to Sinus Rhythm2017 · 23 citations
  4. 4Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis2022 · 10 citations
  5. 5Natural History of Hypertrophic Cardiomyopathy1995 · 264 citations