Key result
High nutrition risk in critical care patients is associated with significantly increased QTc interval, Tp-e interval, and Tp-e/QTc ratios, which correlate with calcium and serum albumin levels.
Why the study?
Studies have examined QTc intervals in critical care patients evaluated for nutrition scores, but none have evaluated Tp-e interval, Tp-e/QT ratio, or Tp-e/QTc ratio.
Are QTc interval, Tp-e interval, and Tp-e/QTc ratio increased in critical care patients with high nutrition risk?
Cross-Sectional (n=134)
Are QTc interval, Tp-e interval, and Tp-e/QTc ratio increased in critical care patients with high nutrition risk?
High nutrition risk in critical care patients is associated with prolonged QTc and Tp-e intervals, suggesting an increased risk for fatal cardiac arrhythmias.
May signal arrhythmia vulnerability in high-nutrition-risk ICU patients; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: To our knowledge, there are studies related to QTc interval in critical care patients whose nutrition scores are evaluated but no studies evaluating T-wave peak and end interval (Tp-e interval), Tp-e/QT ratio, and Tp-e/QTc ratio, used to evaluate cardiac arrhythmia risk and ventricular repolarization change rates. Therefore, we aimed to investigate whether there is a change in Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in patients whose nutrition scores are evaluated. METHODS: This study was planned as a retrospective cross-sectional study. Forty-four patients with a risk score of ≤3 were defined as low-risk group, and 45 patients with a score of ≥4 were defined as high-risk group. Forty-five healthy patients of similar age and gender were included in the control group. All patients underwent 12-lead electrocardiography (ECG). The Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio were measured on ECG. The study data were grouped as patients with high Nutritional Risk Screening 2002 (NRS-2002) risk score, low NRS-2002 risk score, and healthy control. RESULTS: QTc interval, Tp-e interval, and Tp-e/QTc ratios were significantly higher in patients with high nutrition risk. In a correlation analysis, Tp-e interval and Tp-e/QTc ratio were found to be independently associated with calcium, corrected calcium, and serum albumin level. CONCLUSION: QTc interval, Tp-e interval, and Tp-e/QTc ratios are significantly increased in patients with high nutrition risk score compared with healthy people and are independently associated with calcium and serum albumin levels; thus, they can be used more effectively in the follow-up of cardiac fatal arrhythmias.
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Avcı et al. (2020) conducted a cross-sectional in Critical care patients (n=134). High nutrition risk (NRS-2002 score ≥4) vs. Low nutrition risk (NRS-2002 score ≤3) and healthy controls was evaluated on QTc interval, Tp-e interval, and Tp-e/QTc ratio. High nutrition risk in critical care patients is associated with significantly increased QTc interval, Tp-e interval, and Tp-e/QTc ratios, which correlate with calcium and serum albumin levels.
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