Key result
Increased epicardial adipose tissue volume is associated with coronary artery disease and can be reduced by interventions such as exercise and SGLT-2 inhibitors.
Why the study?
Perivascular adipose tissue affects vascular homeostasis via adipokines, and increased epicardial adipose tissue (EAT) volume is associated with coronary artery disease, prompting an updated outline of EAT's roles in coronary atherosclerosis.
Epicardial adipose tissue is an active endocrine organ implicated in coronary atherosclerosis, and its volume and inflammatory status can be modulated by exercise and specific antidiabetic medications like SGLT-2 inhibitors.
Adipose tissue serves not only as an energy store or a mechanical cushion, but also as an endocrine organ. Recent evidence revealed that perivascular adipose tissue is involved in vascular homeostasis and pathophysiology of adjacent arteries by producing various adipokines. Epicardial adipose tissue (EAT) is located between the surface of the heart and the visceral layer of the pericardium and surrounds the coronary arteries. Many clinical studies suggest that an increase in EAT volume is associated with coronary artery disease. It has been reported that exercise and some antidiabetic drugs can reduce EAT volume. In this review, we outline recent findings on the roles of EAT in the pathogenesis of coronary atherosclerosis.
No takes yet. Share an insight, caveat, or question.
A 2020 study conducted a review in Coronary Atherosclerosis. Epicardial Adipose Tissue (EAT) was evaluated. Increased epicardial adipose tissue volume is associated with coronary artery disease and can be reduced by interventions such as exercise and SGLT-2 inhibitors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: